2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-135385
    Dihydro Dutasteride
    		99.72%
    Dihydro Dutasteride is a metabolite of Dutasteride. Dutasteride is a potent inhibitor of both 5 alpha-reductase isozymes.
    Dihydro Dutasteride
  • HY-136346
    2-Hydroxy atorvastatin lactone
    2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids.
    2-Hydroxy atorvastatin lactone
  • HY-B1398R
    Ampyrone (Standard)
    Ampyrone (4-Aminophenazone) (Standard) is the analytical standard of Ampyrone (HY-B1398). This product is intended for research and analytical applications. Ampyrone (4-Aminophenazone; 4-Aminoantipyrine) is a reversible and low-damage optical clearing agent and non-selective COX inhibitor based on UV absorption properties. Ampyrone can improve the optical transmittance of mouse skin and other tissues. Ampyrone can induce tissue refractive index matching by enhancing UV absorption, reduce light scattering, and achieve tissue transparency in vivo. Ampyrone reduces the synthesis of prostaglandin PGE2, thereby exerting anti-inflammatory, analgesic and antipyretic effects. Ampyrone inhibits DNA damage, cell apoptosis and immune cell phagocytosis induced by Doxorubicin (HY-15142A) and Cisplatin (HY-17394), etc., and participates in the regulation of toxicity in tumor chemotherapy.
    Ampyrone (Standard)
  • HY-12781
    Desbutyl Lumefantrine
    		99.66%
    Desbutyl Lumefantrine is a metabolite of lumefantrine with antimalarial activity.
    Desbutyl Lumefantrine
  • HY-W013266S
    N4-Acetylsulfamethoxazole-d4
    		98.66%
    N4-Acetylsulfamethoxazole-d4 (Acetylsulfamethoxazole-d4) is the deuterium labeled N4-Acetylsulfamethoxazole (HY-W013266). N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) is the N4-acetylated metabolite of Sulfamethoxazole (HY-B0322).
    N4-Acetylsulfamethoxazole-d<sub>4</sub>
  • HY-136583
    28-Epirapamycin
    28-Epirapamycin is an impurity of Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells.
    28-Epirapamycin
  • HY-400648
    Folic acid methyl ester
    		99.12%
    Folic acid methyl ester is a methyl ester metabolite of folic acid that can be used in the study of neuropsychiatric conditions, such as depression[1].
    Folic acid methyl ester
  • HY-W741872
    5α-Dihydrocortisol
    		98.17%
    5α-Dihydrocortisol (5α-DHF), a metabolite of Hydrocortisone (Cortisol) (HY-N0583), is a steroid hormone. 5α-Dihydrocortisol can enhance the mineralocorticoid activity of aldosterone.
    5α-Dihydrocortisol
  • HY-100646
    (E)-10-Hydroxynortriptyline maleate
    (E)-10-Hydroxynortriptyline maleate is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression.
    (E)-10-Hydroxynortriptyline maleate
  • HY-108229
    6β-Naltrexol
    		99.03%
    6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit.
    6β-Naltrexol
  • HY-108869
    Fodipir
    		99.81%
    Fodipir is an active metabolite of mangafodipir, involved in mangafodipir-mediated cytoprotection against 7β-hydroxycholesterol-induced cell death.
    Fodipir
  • HY-W778830
    Bodipy C12-ceramide
    		99.92%
    Bodipy C12-ceramide (B12Cer) is a fluorescently tagged form of C12-Ceramide (HY-100353) that displays excitation/emission maxima of 505/540 nm, respectively. Bodipy C12-ceramide is formed when acid sphingomyelinase hydrolyzes BODIPY-C12 sphingomyelin in vitro and has been used to quantify acid sphingomyelinase activity in plasma with Niemann-Pick disease.
    Bodipy C12-ceramide
  • HY-109564
    5α-Pregnane-3β,6α-diol-20-one
    		98.0%
    5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells.
    5α-Pregnane-3β,6α-diol-20-one
  • HY-131172
    Prucalopride N-oxide
    Prucalopride N-oxide is a metabolite of Prucalopride (HY-14151) with motility-enhancing effects.
    Prucalopride N-oxide
  • HY-N16375
    (3R,6S)-Bassiatin
    		99.9%
    (3R,6S)-Bassiatin (Compound 5) is an enantiomer of the fungal metabolite Bassiatin (HY-165143). Bassianin is a compound isolated from fungi that has the activity of inhibiting erythrocyte membrane ATPase and causing cell lysis. Its inhibitory effect on ATPase may be due to membrane disruption.
    (3R,6S)-Bassiatin
  • HY-153995B
    D-Ribonic acid ammonium
    D-Ribonic acid ammonium is a metabolite of D-Ribose (HY-113375). Ribonic acid ammonium is associated with genetic variations in ENOSF1 and NUBPL. Ribonic acid ammonium may participate in the mitochondrial energy production process.
    D-Ribonic acid ammonium
  • HY-131272
    Febuxostat dicarboxylic acid impurity
    		98.76%
    Febuxostat dicarboxylic acid impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
    Febuxostat dicarboxylic acid impurity
  • HY-126855A
    Cholic acid 7-sulfate sodium
    		99.9%
    Cholic acid 7-sulfate sodium is a metabolite of the primary bile acid Cholic acid (HY-N0324).
    Cholic acid 7-sulfate sodium
  • HY-W766140
    4-Hydroxy duloxetine β-D-glucuronide sodium
    4-Hydroxy duloxetine β-D-glucuronide (4-Hydroxy duloxetine glucuronide) sodium is a major metabolite of Duloxetine (HY-B0161). 4-Hydroxy duloxetine β-D-glucuronide sodium is promising for research of hepatic or renal impairment.
    4-Hydroxy duloxetine β-D-glucuronide sodium
  • HY-137932
    Resveratrol-3-O-sulfate sodium
    		99.29%
    Resveratrol-3-O-sulfate (sodium) is the metabolite of Resveratrol.
    Resveratrol-3-O-sulfate sodium
Cat. No. Product Name / Synonyms Application Reactivity